SUPPRESSION OF PDHX BY MICRORNA-27B DEREGULATES CELL METABOLISM AND PROMOTES GROWTH IN BREAST CANCER

Abstract Background The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis.MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer.MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened cellular glucose uptak

Family history of tobacco use and use of e-cigarettes have both been associated with increased tobacco use among young adults.However, to our knowledge, these variables have not been considered simultaneously.This study was designed to evaluate the hypothesis that family history of tobacco use would predict tobacco product use over time among young